Coffee ‘may reverse Alzheimer’s’
A possible treatment for dementia?
Drinking five cups of coffee a day could reverse memory problems seen in Alzheimer’s disease, US scientists say.
The Florida research, carried out on mice, also suggested caffeine hampered the production of the protein plaques which are the hallmark of the disease.
Previous research has also suggested a protective effect from caffeine.
But British experts said the Journal of Alzheimer’s disease study did not mean that dementia patients should start using caffeine supplements.
The 55 mice used in the University of South Florida study had been bred to develop symptoms of Alzheimer’s disease.
First the researchers used behavioural tests to confirm the mice were exhibiting signs of memory impairment when they were aged 18 to 19 months, the equivalent to humans being about 70.
Then they gave half the mice caffeine in their drinking water. The rest were given plain water.
The mice were given the equivalent of five 8 oz (227 grams) cups of coffee a day – about 500 milligrams of caffeine.
The researchers say this is the same as is found in two cups of “specialty” coffees such as lattes or cappuccinos from coffee shops, 14 cups of tea, or 20 soft drinks.
When the mice were tested again after two months, those who were given the caffeine performed much better on tests measuring their memory and thinking skills and performed as well as mice of the same age without dementia.
Those drinking plain water continued to do poorly on the tests.
In addition, the brains of the mice given caffeine showed nearly a 50% reduction in levels of the beta amyloid protein, which forms destructive clumps in the brains of dementia patients.
Further tests suggested caffeine affects the production of both the enzymes needed to produce beta amyloid.
The researchers also suggest that caffeine suppresses inflammatory changes in the brain that lead to an overabundance of the protein.
Earlier research by the same team had shown younger mice, who had also been bred to develop Alzheimer’s but who were given caffeine in their early adulthood, were protected against the onset of memory problems.
You can read the entire article at BBC Health News
There are people in church, people in bible studies who say flatly “God never changes his mind.” It makes me wonder if they read their bible. Throughout the Old Testament, God relents many times. Moses negotiates with God. Job negotiates with God. And here, Saul begs God to let him remain King of Israel and Samuel says in verse 29 that God does not change his mind like some mortal – and then, God relents and allows Saul to be King if he submits, exhibits obedience.
Saul goes on to be a pretty terrible king. God is exceedingly patient and merciful with Saul, and then replaces him with the fallible David. God is unchanging in one way – he is exceedingly merciful and patient with our imperfections, so long as we submit to him.
This is from today’s reading in The Lectionary:
1 Samuel 15:24-35
24 Saul said to Samuel, ‘I have sinned; for I have transgressed the commandment of the Lord and your words, because I feared the people and obeyed their voice. 25Now therefore, I pray, pardon my sin, and return with me, so that I may worship the Lord.’ 26Samuel said to Saul, ‘I will not return with you; for you have rejected the word of the Lord, and the Lord has rejected you from being king over Israel.’ 27As Samuel turned to go away, Saul caught hold of the hem of his robe, and it tore. 28And Samuel said to him, ‘The Lord has torn the kingdom of Israel from you this very day, and has given it to a neighbour of yours, who is better than you. 29Moreover, the Glory of Israel will not recant* or change his mind; for he is not a mortal, that he should change his mind.’ 30Then Saul* said, ‘I have sinned; yet honour me now before the elders of my people and before Israel, and return with me, so that I may worship the Lord your God.’ 31So Samuel turned back after Saul; and Saul worshipped the Lord.
32 Then Samuel said, ‘Bring Agag king of the Amalekites here to me.’ And Agag came to him haltingly.* Agag said, ‘Surely this is the bitterness of death.’* 33But Samuel said,
‘As your sword has made women childless,
so your mother shall be childless among women.’
And Samuel hewed Agag in pieces before the Lord in Gilgal.
34 Then Samuel went to Ramah; and Saul went up to his house in Gibeah of Saul. 35Samuel did not see Saul again until the day of his death, but Samuel grieved over Saul. And the Lord was sorry that he had made Saul king over Israel.
OOps. This is one case where God does NOT change his mind. Today’s lesson says immediately after this scene, God tells Saul to go anoint a son of Jesse king of Israel; for a short while, there are two kings of Israel. . .
1 Samuel 16:1-13
16The Lord said to Samuel, ‘How long will you grieve over Saul? I have rejected him from being king over Israel. Fill your horn with oil and set out; I will send you to Jesse the Bethlehemite, for I have provided for myself a king among his sons.’