This is hopeful news from AOL Healthnews My family has a history of living long; my Mother is 92 and still has all her marbles. Staving off dementia is as key as keeping your body fit if you live to be a ripe old age.
Is a Protein in the Brain Key to Alzheimer’s?
By Dennis Thompson, HealthDay News
The malfunction of a protein, tau, is the likely culprit behind Alzheimer’s. When it malfunctions, brain cells die, a study finds.
Monday, November 03, 2014
Malfunction of a key brain protein called tau is the likely culprit behind Alzheimer’s disease and other forms of dementia, a new study in mice concludes.
Neurons — highly specialized nerve cells in the brain — appear to die when tau malfunctions and fails to clear the cells of unwanted and toxic proteins, explained Charbel Moussa, head of the Laboratory for Dementia and Parkinsonism at Georgetown University School of Medicine, in Washington, D.C.
This means drugs that replace the function of tau in these brain cells are likely to slow the progression of Alzheimer’s, he said.
“A strategy like this will give us hope that we can delay or stabilize the disease progression,” Moussa said.
Tau has long been a prime suspect in the search for the cause of Alzheimer’s disease. The brains of Alzheimer’s patients wind up clogged with twisted protein threads made of tau, particularly in regions important to memory.
But researchers have been at a loss to explain why tau might cause Alzheimer’s, and whether the tangles of tau are more important than another hallmark of Alzheimer’s, plaques made of a protein called amyloid beta that fill the spaces between the brain’s nerve cells.
Moussa said his experiments with mice have shown that tau works to keep neurons naturally free of amyloid beta and other toxic proteins.
When tau malfunctions, the neurons begin to spit amyloid beta out into the space between the brain cells, where the protein sticks together and forms plaques, he said.
“When tau does not function, the cell cannot remove the garbage,” Moussa said. The result is cell death, he explained.
Tests on the brain cells of mice revealed that removing all tau impaired the neurons’ ability to clear out amyloid beta, according to findings published Oct. 31 in the journal Molecular Neurodegeneration. But if researchers reintroduced tau into brain cells, the neurons were better able to remove accumulated amyloid beta from the cells.
Moussa said his study suggests the remaining amyloid beta inside the neuron destroys the cells, not the plaques that build up outside. The mouse experiments also showed that fewer plaques accumulate outside the cell when tau is functioning.
Malfunctioning tau can occur as part of the aging process or due to genetic changes. As people grow older, some tau can malfunction while enough normal tau remains to help clear the garbage and keep neurons alive. “That explains the confusing clinical observations of older people who have plaque buildup, but no dementia,” Moussa explained in a Georgetown University news release.
In this study, Moussa also explored the possible use of a cancer drug called nilotinib to force neurons to keep themselves free of garbage, with the help of some remaining functional tau.
“This drug can work if there is a higher percentage of good to bad tau in the cell,” added Moussa, whose work was funded in part by a grant from Merck & Co., the pharmaceutical company.
Heather Snyder, director of medical and scientific operations for the Alzheimer’s Association, said Moussa’s findings are interesting but not conclusive.
“They’re saying that tau may have an earlier role than we currently know. That’s as far as I would go,” Snyder said. “We still don’t know how all the pieces come together.”
Snyder said new imaging technology that allows doctors to track tau buildup in a person’s brain over time may help solve this question in the future.
Also, experts say, results of animal experiments don’t necessarily apply to humans.
But Dr. Ronald Petersen, director of the Mayo Clinic Alzheimer’s Disease Research Center, said the new study adds to the growing evidence that “the role of tau is fundamental in the disease process.”
“Developing therapeutics for tau is a high priority,” Petersen said. “Not easy, not simple, but it could be very fruitful.”
This from yesterday’s Arab Times Kuwait:
‘Kuwait In Fight With Drugs, Money-Wash’UN Briefed On Efforts
NEW YORK, Oct 10, (KUNA): A Kuwaiti diplomat has briefed a United Nations commission about the State of Kuwait efforts to combat money laundering and other illegal financial activities as well as menace of narcotics. Ibrahim Faisal Al-Da’ee, the third secretary serving with the permanent Kuwaiti mission at the UN, in an address to the UN Social, Cultural and Humanitarian Affairs Committee (SOCHUM), underscored necessity of taking effective action against crime and boosting coordination at the international and regional levels in this respect. As to combating “corrupt financial activities and funding from illegitimate resources,” the third diplomat noted that the State of Kuwait issued lawinto- decree number 23 in 2012, setting up the public authority for combating corruption and issuing special rules for financial assets’ disclosure, as well as the Ministerial Resolution No. 37 (2013), containing executive regulations for combating money laundering and terrorism funding.
On basis of the above mentioned, diplomat Al-Da’ee continued, the national commission for combating money laundering and terrorism was established. Moreover, the Central Bank of Kuwait issued a number of decisions aimed at clamping down on money laundering, in tandem with Kuwait’s endorsement of the UN convention for combating corruption. Regarding the drugs, Kuwait urges for taking necessary precautions to resolve this international problem by means such as encouraging planting of legitimate crops and improving living conditions in rural regions. Also in this respect, he pointed out, Kuwait had signed international conventions concerning such issues. According to Kuwait’s Ministry of Interior, number of drug-related crimes, during 2010-2013, dropped 6.4 percent, drug dealing cases 7.2 percent and narcotics-linked deaths 30 percent. He concluded his address to the international commission, stressing on respect for human and basic rights, through action against crimes, urging for collective global efforts against narcotics.
So . . . now we have legislation and a decree. Does Kuwait have the resources and/or the will to go after those who are funneling the funds to ISIS? Legislations and decrees are great, but even greater is following through; it gives a government credibility.
A reading from today’s Forward Day by Day helps us to cope with the resonating horrors of that monstrous day. We are living in a world where we are more and more inextricably interconnected. Where I am living, I often hear people talk about how “Moslems are killing Christians all over the world!” and my heart breaks, thinking of the wonderful friends I have lived among is so many Moslem countries, their kindness, their hospitality, our long pleasant conversations. I learned so much.
I am glad we believe in a God who knows our hearts. I am thankful for grace, and forgiveness. When we talk about killing, we also need to take account for all the civilians we have killed, trying to bring about peace, trying to eradicate Al Qaeda, Al Shebaab, those who would harm us.
God asks us to love one another. He doesn’t say “Christians, you love just the Christians.” He shows us how to love the Samaritans, the lame, the blind, the mentally ill, the “other”. He tells us, clearly, to love our enemies. The Gospel that speaks the loudest is the gospel of our lives lived to honor him.
THURSDAY, September 11
Acts 15:8-9 [Peter said], “And God, who knows the human heart, testified to them…and in cleansing their hearts by faith he has made no distinction between them and us.”
Thirteen years ago, this day became one of those days that divide time into what life was like before, and after; one of those days when you will remember, always, where you were, what you were doing—this time when you heard the news that airplanes had crashed into the World Trade Center and thousands of people had died.
Job asks, “Does not calamity befall the unrighteous?” (31:3), but we learned, vividly, on September 11, 2001, that the righteous and the innocent suffer too.
Psalm 59:6 exhorts God to “show no mercy to those who are faithless and evil.” The terrorists who flew the planes on 9/11 forced us to confront the power of evil and challenged us to find a way to respond with forgiveness. Perhaps we can learn something about that in Peter’s response to the heated discussions about Jews and Gentiles, about who could be saved, and how: “God, who knows the human heart…has made no distinction between them and us” (Acts 15:8-9).
Then, as now, there were good people and evildoers on all sides, religions, and races. Now, as then, judgment and salvation comes only through the mercy and grace of God.
Its been a sad couple of months, starting with our cat’s death, and a friend’s death. We grieve Pete, we miss him, and we ask ourselves if we made a big mistake thinking a knee operation would be the right thing, if he would have lived happily without it? Pete was in pain. There were days he couldn’t go up the stairs. There were days he spent almost the entire day in his heated bed. We didn’t see a lot of options. Other sad news has hit; it feels like a season of losses.
In the Lectionary readings, we are reading Job, Ayyoub, and I think if my friend who said “Al-hamdallah!” when I told her my father is dying. I learned so much from her. She made me understand I am to thank God even for the bad things, it is God’s will, and a part of a bigger picture I will never see. And then this morning, I saw a reference to an old post, a post from 2006, a post I don’t even remember writing.
Sandra felt as low as the heels of her shoes as she pushed against a November gust and the florist shop door.
Her life had been easy, like a spring breeze. Then in the fourth month of her second pregnancy, a minor automobile accident stole that from her.
During this Thanksgiving week she would have delivered a son. She grieved over her loss. As if that weren’t enough, her husband’s company threatened a transfer. Then her sister, whose holiday visit she coveted, called saying she could not come for the holiday.
Then Sandra’s friend infuriated her by suggesting her grief was a God-given path to maturity that would allow her to empathize with others who suffer. She has no idea what I’m feeling, thought Sandra with a shudder.
Thanksgiving? Thankful for what? She wondered. For a careless driver whose truck was hardly scratched when he rear-ended her? For an airbag that saved her life but took that of her child?
“Good afternoon, can I help you?” The shop clerk’s approach startled her.
“I….I need an arrangement,” stammered Sandra.
“For Thanksgiving? Do you want beautiful but ordinary, or would you like to challenge the day with a customer favorite I call the Thanksgiving “Special?” asked the shop clerk. “I’m convinced that flowers tell stories,” she continued. “Are you looking for something that conveys ‘gratitude’ this thanksgiving?”
“Not exactly!” Sandra blurted out. “In the last five months, everything that could go wrong has gone wrong.”
Sandra regretted her outburst, and was surprised when the shop clerk said, “I have the perfect arrangement for you.”
Just then the shop door’s small bell rang, and the shop clerk said, “Hi, Barbara…let me get your order.” She politely excused herself and walked toward a small workroom, then quickly reappeared, carrying an arrangement of greenery, bows, and long-stemmed thorny roses. Except the ends of the rose stems were neatly snipped: there were no flowers.
“Want this in a box?” asked the clerk.
Sandra watched for the customer’s response. Was this a joke? Who would want rose stems with no flowers! She waited for laughter, but neither woman laughed.
“Yes, please,” Barbara, replied with an appreciative smile. “You’d think after three years of getting the special, I wouldn’t be so moved by its significance, but I can feel it right here, all over again,” she said as she gently tapped her chest. And she left with her order.
“Uh,” stammered Sandra, “that lady just left with, uh….she just left with no flowers!
“Right, said the clerk, “I cut off the flowers. That’s the Special. I call it the Thanksgiving Thorns Bouquet.”
“Oh, come on, you can’t tell me someone is willing to pay for that!” exclaimed Sandra.
“Barbara came into the shop three years ago feeling much like you feel today,” explained the clerk. “She thought she had very little to be thankful for. She had lost her father to cancer, the family business was failing, her son was into drugs, and she was facing major surgery.”
“That same year I had lost my husband,” continued the clerk, “and for the first time in my life, had just spent the holidays alone. I had no children, no husband, no family nearby, and too great a debt to allow any travel.”
“So what did you do?” asked Sandra.
“I learned to be thankful for thorns,” answered the clerk quietly. “I’ve always thanked God for the good things in my life and never questioned the good things that happened to me, but when bad stuff hit, did I ever ask questions! It took time for me to learn that dark times are important. I have always enjoyed the ‘flowers’ of life, but it took thorns to show me the beauty of God’s comfort. You know, the Bible says that God comforts us when we’re afflicted, and from His consolation we learn to comfort others.”
Sandra sucked in her breath as she thought about the very thing her friend had tried to tell her. “I guess the truth is I don’t want comfort. I’ve lost a baby and I’m angry with God.”
Just then someone else walked in the shop. “Hey, Phil!” shouted the clerk to the balding, rotund man.
“My wife sent me in to get our usual Thanksgiving Special….12 thorny, long-stemmed stems!” laughed Phil as the clerk handed him a tissue-wrapped arrangement from the refrigerator.
“Those are for your wife?” asked Sandra incredulously. “Do you mind me asking why she wants something that looks like that?”
“No…I’m glad you asked,” Phil replied. “Four years ago my wife and I nearly divorced. After forty years, we were in a real mess, but with the Lord’s grace and guidance, we slogged through problem after problem. He rescued our marriage. Jenny here (the clerk) told me she kept a vase of rose stems to remind her of what she learned from “thorny” times, and that was good enough for me. I took home some of those stems. My wife and I decided to label each one for a specific “problem” and give thanks for what that problem taught us.”
As Phil paid the clerk, he said to Sandra, “I highly recommend the Special!”
“I don’t know if I can be thankful for the thorns in my life.” Sandra said. “It’s all too…fresh.”
“Well,” the clerk replied carefully, “my experience has shown me that thorns make roses more precious. We treasure God’s providential care more during trouble than at any other time. Remember, it was a crown of thorns that Jesus wore so we might know His love. Don’t resent the thorns.”
Tears rolled down Sandra’s cheeks. For the first time since the accident, she loosened her grip on resentment. “I’ll take those twelve long-stemmed thorns, please,” she managed to choke out.
“I hoped you would,” said the clerk gently. “I’ll have them ready in a minute.”
“Thank you. What do I owe you?”
“Nothing. Nothing but a promise to allow God to heal your heart. The first year’s arrangement is always on me.” The clerk smiled and handed a card to Sandra. “I’ll attach this card to your arrangement, but maybe you would like to read it first.”
It read: “My God, I have never thanked You for my thorns. I have thanked You a thousand times for my roses, but never once for my thorns. Teach me the glory of the cross I bear; teach me the value of my thorns. Show me that I have climbed closer to You along the path of pain. Show me that, through my tears, the colors of Your rainbow look much more brilliant.”
Praise Him for your roses; thank him for your thorns!
I know God can bring great good out of all things. I have seen this in my own life, out of the worst circumstances can come good I could never have foreseen. I am praying this fervently; that he will bring great good out of all circumstances.
Every time I see this commercial, it gives me a big grin. These little babies and children need so much attention, and we applaud the loving care their parents put into cherishing them, sustaining them, nurturing them, civilizing them, educating them, exercising them, and sharing with them until they can care for themselves.
Young parents, you are doing the toughest job in the world. We see you. We see your sacrifices, and the effects of sleep deprivation, we see you giving, giving, giving to those who cannot give back, and we are in awe of your loving patience to your children.
I also love it that men are also featured prominently as caregivers :-)
His name was Pete. He died last night. The operation was a success, but the shock to his system caused his kidneys to fail. We are grieving, and having a very very bad day.
We are heartsick.
This little cat was a blessing to us for 11 years. He came to us a skittish little street cat in Qatar. While AdventureMan worked long hours, he kept me company, helping me quilt, entertaining my friends, almost always in the same room or close by. When AdventureMan would come home, he would play hide-and-seek with him and adored AdventureMan with all his little heart. I was the Mama; AdventureMan was the FunGuy.
He was not such a little cat; he was only a kitten in his own mind. He was a very long cat, and appeared much bigger than he really was because of his length, and his big long fur, which made him a fluffy cat. He was polite, always greeting us when we came in, and talking to us when we were sitting together.
He leaves a great hole in our hearts. Rest in Peace, Sweet Kitty.
Today I got this. It’s a common name; it’s entirely possible I know someone of that name, but I have never seen a notice like this, official, impersonal, and not mentioning the specific name of the deceased. It smells. No. It stinks.
First, we really love eating at the Hanger at the Wharf. So does just about everyone else. Twice, we got really lucky. It is easier getting a table if you are just two people, and it is easier getting a table if you eat early. As we are still on Pensacola tummy time, we are in luck. As the Celebration 2014 parade ended, we zipped straight over and as larger groups waited, we were immediately shown to a table for two.
No wonder The Hanger is so popular. The food is terrific and this is the view – straight down the Gastineau channel with Douglas and the cruise ships. As the sun slides behind the mountain, it is a stunning view:
Some hardier souls were eating outside on the deck. I used to be this hardy, but my years in the Middle East have softened me, made me not so good at eating in cool and drafty places, even in the middle of the Alaskan summer.
Inside The Hanger: great, courteous, friendly and efficient employees
Every table taken, the bar is packed, and people are waiting in the hallway to be seated:
We liked the food and atmosphere so well that we went back a second time during the ceremonial dances and were happy to see a lot of the dancers eating there, too. I had the first mate’s plate, with salmon and halibut and a berry chutney and AdventureMan had grilled halibut. We both left happy. We would go there again in a heartbeat.
There is only one little thing about The Hanger that makes me uneasy, and it has nothing to do with The Hanger. When I was a little girl, living across the channel, I would watch for my Dad to come home – this was the airport for the amphibious planes, Alaska Coastal Airlines (now part of Alaska Airlines) and Ellis Airlines. When his plane would land, we would all rush to the car and drive like crazy across the bridge to pick him up (no cell phones then, LOL). So I still feel a little frisson and feel the ghosts of the past when I eat there.